1999•Bioorganic & Medicinal Chemistry LettersOpen access

Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors

Celia Dominguez, Daniel E. Duffy, Qi Han, Richard Alexander, Robert A. Galemmo, Jeongsook M. Park, Pancras C. Wong, Eugene C. Amparo, Robert M. Knabb, Joseph M. Luettgen, Ruth R. Wexler

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Key concepts: Thrombin, Chemistry, Serine protease, Discovery and development of direct thrombin inhibitors, Indole test, Active site, Antithrombins, Stereochemistry

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Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors — Research Paper | ScholarLens