2015•Bioorganic & Medicinal ChemistryOpen access

Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors

Dongxing Chen, Shaochi Wang, Xiao-Juan Diao, Qihua Zhu, Hui-liang Shen, Xueqing Han, Yiwei Wang, Guoqing Gong, Yungen Xu

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Key concepts: Chemistry, Discovery and development of direct thrombin inhibitors, Dabigatran, Thrombin, Antithrombins, Serine protease, Pharmacology, Direct thrombin inhibitor

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Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors — Research Paper | ScholarLens