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Synthesis of related substances of olmesartan medoxomil, an anti-hypertensive drug

Karrothu Srihari Babu, Amirisetty Ravindranath Tagore, G. Saikiran Reddy, Gandu Venkateswarlu, Padi Pratap Reddy, Ramasamy Vijaya Anand

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Abstract

Olmesartan medoxomil 1 is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension.During the process development of olmesartan medoxomil, four related substances (impurities) were observed along with the final API.Those impurities were identified as olmesartan acid, 4-acetyl olmesartan, 5-acetyl olmesartan, and dehydro olmesartan.Present work describes the synthesis and characterization of all these four impurities.

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What this paper is about

Olmesartan medoxomil 1 is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension.During the process development of olmesartan medoxomil, four related substances (impurities) were observed along with the final API.Those impurities were identified as olmesartan acid, 4-acetyl olmesartan, 5-acetyl olmesartan, and dehydro olmesartan.Present work describes the synthesis and characterization of all these four impurities.

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Available abstract

Olmesartan medoxomil 1 is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension.During the process development of olmesartan medoxomil, four related substances (impurities) were observed along with the final API.Those impurities were identified as olmesartan acid, 4-acetyl olmesartan, 5-acetyl olmesartan, and dehydro olmesartan.Present work describes the synthesis and characterization of all these four impurities.

Key concepts: Olmesartan, Chemistry, Pharmacology, Drug, Antagonist, Angiotensin II receptor antagonist, Angiotensin receptor, Angiotensin II

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