2005Antimicrobial Agents and ChemotherapyOpen access

Presence of Tetracycline Resistance Determinants and Susceptibility to Tigecycline and Minocycline

Ad C. Fluit, A. Florijn, J. Verhoef, D. Milatović

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Abstract

No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.

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No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.

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Available abstract

No relation between the presence of tetracycline resistance determinants tet(A) to tet(E) and the MICs of tigecycline was observed for Enterobacteriaceae, although tetracycline-susceptible isolates were more susceptible overall to tigecycline, whereas the presence of tet(M) in Staphylococcus aureus was associated with higher MICs of minocycline.

Key concepts: Tigecycline, Minocycline, Tetracycline, Microbiology, Staphylococcus aureus, Enterobacteriaceae, Antibacterial agent, Biology

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