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2007•Chemical and Pharmaceutical BulletinOpen access

Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments (1). Synthesis of 4-Hydroxyquinoline-.BETA.-glucosides

Hiroshi Suzuki, Nagwa S. M. Aly, Yusuke Wataya, Hye‐Sook Kim, Ikumi Tamai, Masaki Kita, Daisuke Uemura

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Abstract

Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-beta-glucosides from anilines in 4 steps.

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Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-beta-glucosides from anilines in 4 steps.

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Available abstract

Quinoline hexose analogs are expected to be useful as novel agents for treatment of chloroquine-resistant malaria. Here, we report preparation of 4-hydroxy quinoline-beta-glucosides from anilines in 4 steps.

Key concepts: Quinoline, Chemistry, Chloroquine, Plasmodium falciparum, Malaria, Hexose, 8-Hydroxyquinoline, Quinine

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