2009•BULGARIAN JOURNAL OF VETERINARY MEDICINEOpen access
REFERENCE VALUES OF OXIDATIVE STRESS PARAMETERS IN ADULT NATIVE IRANIAN GOATS
Saeed Nazıfı, M. Saeb, Narjes Ghafari, Iman Razeghian, Seyed Mostafa Razavi, F. Vosoughi, Fatemeh Dehghani, H. Orangi
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Abstract
Summary Nazifi, S., M. Saeb, N. Ghafari, I. Razeghian, S. M. Razavi, F. Vosoughi, F. Dehghani& H. Orangi, 2009. Reference values of oxidative stress parameters in adult native Iranian goats. Bulg. J. Vet. Med. , 12 , No 2, 119−124. The present study was performed on 132 clinically healthy Iranian native goats from both sexes (36 male and 96 female). The blood concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were determined. The reference values for oxidative stress parameters of adult clinically healthy Iranian native goats were as followed: SOD 778.65−1190.50 U/g Hb, GPX 266.67−322.00 U/g Hb, CAT 1536.29−2215.63 U/g Hb and MDA 0.346−0.801 μmol/L. There were no significant differences in oxidative stress parameters between the two sexes. Key words : catalase, glutathione peroxidase , Iranian native goats, malondialdehyde, refer-ence values, superoxide dismutase INTRODUCTION A stressful condition leads to the exces-sive production of free radicals, which results in oxidative stress, an imbalance in the oxidant/antioxidant system. Genera-tion of free radicals is an integral feature of normal cellular functions. In contrast, excessive generation and/or inadequate removal of free radicals results in destruc-tive and irreversible damage to the cell (Lopaczyski & Zeisel