2002•FEMS Microbiology LettersRequires access

AbrB is a regulator of the σWregulon inBacillus subtilis

Qian Qiang, Chien Y Lee, John D. Helmann, Mark A. Strauch

Abstract

The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the sigma(W) regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other sigma(W)-dependent promoters in B. subtilis. Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the sigma(W) regulon.

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Key concepts: Regulon, Bacillus subtilis, Sigma factor, Regulator, Psychological repression, Promoter, Operon, Genetics