Clozapine-resistant schizophrenia: A positive approach

Clozapine is widely regarded as the 'gold Clozapine is widely regarded as the 'gold standard' treatment for treatment-resistant standard' treatment for treatment-resistant schizophrenia, after failure of two anti-schizophrenia, after failure of two antipsychotics at adequate doses for an psychotics at adequate doses for an adequate duration of time.However, even adequate duration of time.However, even after 1 year, a number of patients fail to after 1 year, a number of patients fail to respond to clozapine alone.We question respond to clozapine alone.We question the term 'treatment-resistant', which the term 'treatment-resistant', which implies that little further can be done and implies that little further can be done and generates therapeutic nihilism, and instead generates therapeutic nihilism, and instead suggest the term 'neuroleptic-resistant suggest the term 'neuroleptic-resistant schizophrenia' as a more positive alter-schizophrenia' as a more positive alternative.In this editorial we suggest a native.In this editorial we suggest a number of treatment options for patients number of treatment options for patients resistant to clozapine monotherapy, and resistant to clozapine monotherapy, and hope to generate a fresh and positive hope to generate a fresh and positive approach.approach.