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EFFECT OF PRETREATMENT ON LEAD DISTRIBUTION IN LIVER AND BODY OF RAT IN ACUTE LEAD POISONING

Hiroshi Yoshikawa, Takayasu Kato

Abstract

Male rats were given 5 mg/kg of lead intraperitoneally and after an interval of 3 days were given 50 mg/kg of lead intraperitoneally. The distributioh of lead in the body after receiving challenge dose of lead was compared with that of rats non-pretreated with lead. Lead contents of each organ, especially that of liver, of the pretreated rats were found to be reduced. The rate of lead content in nuclei fraction, where lead taken into liver mainly concentrated, to lead content in liver was significantly low in rats pretreated with lead compared with non-pretreated rats after challenging. The rate of lead content in other fractions of liver to lead in liver of pretrerted rats rose from that of non-pretreated rats. From these results, it was recognized that the pretreatment remarkably changes the lead distribution in body and in liver.

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Key concepts: Lead (geology), Lead poisoning, Chemistry, Distribution (mathematics), Internal medicine, Endocrinology, Physiology, Animal science