1983•The Journal of Cell BiologyOpen access

Nuclear RNA-protein interactions and messenger RNA processing.

Thoru Pederson

Abstract

Eucaryotic messenger RNA precursors are processed in nuclear ribonucleoprotein particles (hnRNP). Here recent work on the structure of hnRNP is reviewed, with emphasis on function. Detailed analysis of a specific case, the altered assembly of hnRNP in heat-shocked Drosophila and mammalian cells, leads to a general hypothesis linking hnRNP structure and messenger RNA processing.

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Key concepts: Biology, Ribonucleoprotein, RNA, Heterogeneous nuclear ribonucleoprotein, Messenger RNP, Messenger RNA, Mature messenger RNA, Five-prime cap