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1964•Archives of Disease in ChildhoodOpen access

The Effect of Human Growth Hormone in Hypopituitary Dwarfism

A Prader, R Illig, Judith Széky, H Wagner

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Abstract

Pituitary growth hormone is a polypeptide molecule with a wide range of effects on protein, lipid, and carbohydrate metabolism (Korner, 1961; Raben, 1962; Finkel, 1962; Sirek and Sirek, 1964; Knobil and Hotchkiss, 1964).It promotes growth through its protein anabolic (nitrogen-retaining) effect.Growth hormones from different species show differences in physical, chemical, and immunological properties and a marked degree of species specificity in their physiological activity.In man only human growth hormones are effective.The molecular weight of human gowth hormone (HGH) is 29,000.Its structure is not yet exactly known.As yet it can only be obtained by extracting human pituitaries gained at necropsy.The amount available is, therefore, still seriously limited.In 1958 Raben published the first report of the successful treatment of a hypopituitary dwarf with HGH.Since then considerable experience has accumulated (Hutchings, Escamilla,

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Pituitary growth hormone is a polypeptide molecule with a wide range of effects on protein, lipid, and carbohydrate metabolism (Korner, 1961; Raben, 1962; Finkel, 1962; Sirek and Sirek, 1964; Knobil and Hotchkiss, 1964).It promotes growth through its protein anabolic (nitrogen-retaining) effect.Growth hormones from different species show differences in physical, chemical, and immunological properties and a marked degree of species specificity in their physiological activity.In man only human growth hormones are effective.The molecular weight of human gowth hormone (HGH) is 29,000.Its structure is not yet exactly known.As yet it can only be obtained by extracting human pituitaries gained at necropsy.The amount available is, therefore, still seriously limited.In 1958 Raben published the first report of the successful treatment of a hypopituitary dwarf with HGH.Since then considerable experience has accumulated (Hutchings, Escamilla,

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Available abstract

Pituitary growth hormone is a polypeptide molecule with a wide range of effects on protein, lipid, and carbohydrate metabolism (Korner, 1961; Raben, 1962; Finkel, 1962; Sirek and Sirek, 1964; Knobil and Hotchkiss, 1964).It promotes growth through its protein anabolic (nitrogen-retaining) effect.Growth hormones from different species show differences in physical, chemical, and immunological properties and a marked degree of species specificity in their physiological activity.In man only human growth hormones are effective.The molecular weight of human gowth hormone (HGH) is 29,000.Its structure is not yet exactly known.As yet it can only be obtained by extracting human pituitaries gained at necropsy.The amount available is, therefore, still seriously limited.In 1958 Raben published the first report of the successful treatment of a hypopituitary dwarf with HGH.Since then considerable experience has accumulated (Hutchings, Escamilla,

Key concepts: Dwarfism, Medicine, Human growth hormone, Growth hormone, Endocrinology, Hypopituitarism, Internal medicine, Hormone

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