1965•European Journal of EndocrinologyRequires access

METABOLISM OF PREGNENOLONE-3-SULPHATE IN THE PERFUSED DOG LIVER

K. D. Voigt, J. Tamm, U. Volkwein, H Schedewie

Abstract

ABSTRACT Pregnenolone-sulphate (400 mg) was perfused through isolated dog livers. The following steroids were isolated in the perfusate: pregnenolone, progesterone, dehydroepiandrosterone, androst-5-ene-diol and the two steroid conjugates, i. e. pregnenolone-sulphate and dehydroepiandrosterone-sulphate. Two »free« steroids and one steroid conjugate could not be characterized. A tentative scheme for the metabolic pathways of pregnenolone-sulphate is presented.

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Key concepts: Pregnenolone, Androsterone, Endocrinology, Internal medicine, Steroid, Metabolism, Chemistry, Conjugate