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Analgesic and Antipyretic Properties of Some Aspirin Derivatives

Lawrence C. Weaver, Alice B. Richards, Heather Martin

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Abstract

Abstract Several derivatives of acetylsalicylic acid have been tested for analgesic and antipyretic properties in mice and rats. o-Diphenylacetoxy benzoic acid (O-(diphenylacetyl)salicylic acid; DPA) is a superior analgesic but an inferior antipyretic to aspirin, DPA has a low toxicity: it failed to show significant anti-inflammatory or tranquillising properties. In dogs it produced only slight and transient falls in blood pressure and there was no appreciable effect on the direct or reflex muscle preparation.

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What this paper is about

Abstract Several derivatives of acetylsalicylic acid have been tested for analgesic and antipyretic properties in mice and rats. o-Diphenylacetoxy benzoic acid (O-(diphenylacetyl)salicylic acid; DPA) is a superior analgesic but an inferior antipyretic to aspirin, DPA has a low toxicity: it failed to show significant anti-inflammatory or tranquillising properties. In dogs it produced only slight and transient falls in blood pressure and there was no appreciable effect on the direct or reflex muscle preparation.

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Available abstract

Abstract Several derivatives of acetylsalicylic acid have been tested for analgesic and antipyretic properties in mice and rats. o-Diphenylacetoxy benzoic acid (O-(diphenylacetyl)salicylic acid; DPA) is a superior analgesic but an inferior antipyretic to aspirin, DPA has a low toxicity: it failed to show significant anti-inflammatory or tranquillising properties. In dogs it produced only slight and transient falls in blood pressure and there was no appreciable effect on the direct or reflex muscle preparation.

Key concepts: Antipyretic, Analgesic, Aspirin, Salicylic acid, Anesthesia, Medicine, Benzoic acid, Reflex

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