2006•The Journal of Organic ChemistryRequires access
Base−Base Interactions in the Minor Groove of Double-Stranded DNA
Tongfei Wu, Koen Nauwelaerts, Arthur A. Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet A. Herdewijn
Open publisher page 41 citations
Abstract
A method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A-T base interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex and are separated from each other by one regular base pair.