ABSORPTION AND EXCRETION OF 35S DAPSONE IN DERMATITIS HERPETIFORMIS

SUMMARY.– The variability of dosage of dapsone required to control dermatitis herpetiformis is well known but unexplained. As a first step in the investigation of this problem this paper describes the results of estimations of serum levels and urinary excretion levels after a single oral dose of 100 mg. 35S dapsone given to patients with and without dermatitis herpetiformis. For comparison the levels were measured by radio‐activity and by chemical methods. Radiochromatographic studies were also carried out to determine the form in which dapsone circulates and is excreted. Autoradiographs of biopsies are also discussed.