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2006•British Journal of DermatologyRequires access

Dapsone acetylation in dermatitis herpetiformis

G.A. Ellard, Patricia T. Gammon, John A. Savin, R. Tan

Open publisher page 32 citations

Abstract

The metabolism of dapsone was studied in ten patients with proven dermatitis herpetiformis. Seven of the patients, who were slow acetylators of sulphadimidine, also acetylated dapsone slowly. Three of the patients were rapid acetylators of both drugs. The control of symptoms did not seem to be related to the plasma concentrations of dapsone or of its metabolite monoacetyldapsone. Haemato‐logical side effects, however, were related to plasma dapsone concentrations.

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What this paper is about

The metabolism of dapsone was studied in ten patients with proven dermatitis herpetiformis. Seven of the patients, who were slow acetylators of sulphadimidine, also acetylated dapsone slowly. Three of the patients were rapid acetylators of both drugs. The control of symptoms did not seem to be related to the plasma concentrations of dapsone or of its metabolite monoacetyldapsone. Haemato‐logical side effects, however, were related to plasma dapsone concentrations.

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Available abstract

The metabolism of dapsone was studied in ten patients with proven dermatitis herpetiformis. Seven of the patients, who were slow acetylators of sulphadimidine, also acetylated dapsone slowly. Three of the patients were rapid acetylators of both drugs. The control of symptoms did not seem to be related to the plasma concentrations of dapsone or of its metabolite monoacetyldapsone. Haemato‐logical side effects, however, were related to plasma dapsone concentrations.

Key concepts: Dapsone, Dermatitis herpetiformis, Dermatology, Metabolite, Medicine, Pharmacology, Internal medicine, Disease

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