2014•Applied Mechanics and MaterialsRequires access

The Study of Oxymatrine on Apoptosis of Human Carcinoma Cell Line MGC-803 by Flow Cytometry

Yan Qin Zhu, Nan Nan Zheng, Lu Tang, Xi Feng Li

Abstract

Objective:To study the effect of oxymatrine on apoptosis of human carcinoma cell line MGC-803. Methods:Flow cytometry were conducted to investigate apoptosis rate and expression of Bcl-2 and Bax protein. Results: At the dose of oxymatrine were 1mg/ml,2mg/ml,the apoptosis rates in MGC-803 were higher than those of controls (p<0.05), the expression of Bcl-2 was decreased and Bax was increased significantly (p<0.05).Conclusion:Oxymatrine induces apoptosis in human carcinoma cell line MGC-803, its mechanism includes up-regulated expression of Bax and down-regulated expression of Bcl-2.

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Key concepts: Oxymatrine, Apoptosis, Flow cytometry, BAX Protein, Cell culture, Cell, Chemistry, Cancer research