Apolipoprotein and lipoprotein synthesis and modifications
Vassilis I. Zannis, Christos Cladaras, Eleni E. Zanni
Abstract
Vassilis I. Zannis, Christos Cladaras, Eleni E. Zanni
Abstract
Conventional and molecular biological approaches have defined the sites of apolipoprotein synthesis and have described intra- and extracellular apolipoprotein modifications. Topics selected for discussion in this review include new aspects of apolipoprotein synthesis and modifications, modification of apolipoprotein B byproducts of lipid oxidation, remodeling of lipoproteins by transfer of apolipoproteins and functional significance, in vivo and in vitro assembly of apolipoprotein B-containing lipoproteins, and intracellular versus extracellular assembly of high-density lipoprotein and lipoprotein-type particles.
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Conventional and molecular biological approaches have defined the sites of apolipoprotein synthesis and have described intra- and extracellular apolipoprotein modifications. Topics selected for discussion in this review include new aspects of apolipoprotein synthesis and modifications, modification of apolipoprotein B byproducts of lipid oxidation, remodeling of lipoproteins by transfer of apolipoproteins and functional significance, in vivo and in vitro assembly of apolipoprotein B-containing lipoproteins, and intracellular versus extracellular assembly of high-density lipoprotein and lipoprotein-type particles.
Key concepts: Apolipoprotein B, Apolipoprotein C2, Lipoprotein, Chemistry, Apolipoprotein E, Extracellular, Biochemistry, Intracellular