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1984•The Journal of Clinical Endocrinology & MetabolismRequires access

BLOCKADE OF hp-GRF-40-INDUCED GH RELEASE IN NORMAL MEN BY A CHOLINERGIC MUSCARINIC ANTAGONIST

FERDINANDO MASSARA, Ezio Ghigo, STEFANIA GOFFI, Gian Michele Molinatti, Eugenio E. Müller, Franco Camanni

Open publisher page 73 citations

Abstract

In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH-releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.

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What this paper is about

In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH-releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.

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OpenAlex reports 73 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH-releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.

Key concepts: Pirenzepine, Endocrinology, Internal medicine, Muscarinic acetylcholine receptor, Antagonist, Somatostatin, Cholinergic, Muscarinic antagonist

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BLOCKADE OF hp-GRF-40-INDUCED GH RELEASE IN NORMAL MEN BY A CHOLINERGIC MUSCARINIC ANTAGONIST — Research Paper | ScholarLens