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1984•Journal of NeurochemistryRequires access

Evidence for Multiple Muscarinic Receptor Subtypes in Human Brain

Janice M. Garvey, Martin N. Rossor, Leslie L. Iversen

Open publisher page 23 citations

Abstract

Pirenzepine, a compound with selective antimuscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC50 values derived from the inhibition of specific [3H]L-quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.

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What this paper is about

Pirenzepine, a compound with selective antimuscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC50 values derived from the inhibition of specific [3H]L-quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.

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OpenAlex reports 23 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Pirenzepine, a compound with selective antimuscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC50 values derived from the inhibition of specific [3H]L-quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.

Key concepts: Pirenzepine, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Quinuclidinyl Benzilate, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M3

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