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1969•Acta Medica ScandinavicaRequires access

MONOAMINE OXIDASE ACTIVITY IN THE HUMAN SMALL INTESTINE

O Mustala, E Solatunturi, S Tarpila

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Abstract

Abstract.Monoamine oxidase (MAO) activity in the epithelium of the normal human small intestine was found to be very high, 28.0 nmol IAA/mg/h, which is higher than the MAO activity in other tissues according to earlier studies. After nialamide treatment (150 mg/day orally) for two weeks the activity was reduced by 85%. This is about the same as that seen after pargyline and isocarboxazide treatment and cannot be the explanation of the lesser complications with nialamide. Merely the decrease of MAO activity in the epithelium of the small intestine is probably a very important factor in the development of the circulatory reactions from which patients treated with monoamine oxidase inhibitors suffer after ingesting certain foods containing monoamines. The measurement of MAO activity in the intestinal mucosa was found to be a useful method for clinical work.

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Abstract.Monoamine oxidase (MAO) activity in the epithelium of the normal human small intestine was found to be very high, 28.0 nmol IAA/mg/h, which is higher than the MAO activity in other tissues according to earlier studies. After nialamide treatment (150 mg/day orally) for two weeks the activity was reduced by 85%. This is about the same as that seen after pargyline and isocarboxazide treatment and cannot be the explanation of the lesser complications with nialamide. Merely the decrease of MAO activity in the epithelium of the small intestine is probably a very important factor in the development of the circulatory reactions from which patients treated with monoamine oxidase inhibitors suffer after ingesting certain foods containing monoamines. The measurement of MAO activity in the intestinal mucosa was found to be a useful method for clinical work.

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Available abstract

Abstract.Monoamine oxidase (MAO) activity in the epithelium of the normal human small intestine was found to be very high, 28.0 nmol IAA/mg/h, which is higher than the MAO activity in other tissues according to earlier studies. After nialamide treatment (150 mg/day orally) for two weeks the activity was reduced by 85%. This is about the same as that seen after pargyline and isocarboxazide treatment and cannot be the explanation of the lesser complications with nialamide. Merely the decrease of MAO activity in the epithelium of the small intestine is probably a very important factor in the development of the circulatory reactions from which patients treated with monoamine oxidase inhibitors suffer after ingesting certain foods containing monoamines. The measurement of MAO activity in the intestinal mucosa was found to be a useful method for clinical work.

Key concepts: Nialamide, Monoamine oxidase, Pargyline, Monoamine oxidase inhibitor, Monoamine neurotransmitter, Small intestine, Internal medicine, Endocrinology

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