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2013•Journal of VirologyOpen access

NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon

Emilie Chauveau, Virginie Doceul, Estelle Lara, Emmanuel Bréard, Corinne Sailleau, Pierre‐Olivier Vidalain, ELIANE F. MEURS, Stéphanie Dabo, Isabelle Schwartz-Cornil, Stéphan Zientara, Damien Vitour

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Abstract

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

About this research paper

What this paper is about

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

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OpenAlex reports 70 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

Key concepts: Biology, Virology, Interferon, Virus, NS3, Interferon type I, Orbivirus, In vivo

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