2008•Chemical CommunicationsRequires access

Ni–nitrilotriacetic acid-modified quantum dots as a site-specific labeling agent of histidine-tagged proteins in live cells

Junwon Kim, Hyeyoung Park, Jaeseung Kim, Ji Young Ryu, Do Yoon Kwon, Régis Grailhe, Rita Song

Abstract

Ni-nitrilotriacetic acid (NTA) functionalized CdSe/ZnS quantum dots (QDs) were exploited as a site-specific labeling agent of histidine-tagged biomolecules in live cells; the QDs were found to be water-soluble, aggregation free and stable for several months.

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Key concepts: Nitrilotriacetic acid, Histidine, Quantum dot, Biomolecule, Chemistry, Nanotechnology, Combinatorial chemistry, Biophysics