1987•Journal of NeurochemistryRequires access

Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide

Chris Shaw, L. Thim, J. Michael Conlon

Abstract

The primary structure of gastrin-releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin-releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin-releasing peptide and its COOH-terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin-releasing peptide. Within the small intestine, highest concentrations of gastrin-releasing peptide-like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.

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Key concepts: Gastrin-releasing peptide, Gastrin, Edman degradation, Guinea pig, Peptide, Stomach, Small intestine, Chemistry