1986•Experimental Biology and MedicineRequires access

Comparison of the Actions of Bombesin, Gastrin-Releasing Peptide-27, Neuromedin B, and Gastrin-Releasing Peptide-10 in Causing Release of Gastrin and Gastric Inhibitory Peptide in Rats

George H. Greeley, Alan W. Spannagel, FREDDIE L.C. HILL, J. C. Thompson

Abstract

The objective of this study was to compare the gastrin- and gastric inhibitory peptide (GIP)-releasing actions of bombesin, gastrin-releasing peptide (GRP)-27, neuromedin B, and GRP-10 in rats. Both bombesin and GRP-27 are potent stimulants of gastrin and GIP release, whereas neuromedin B and GRP-10 are less effective, on a molar basis.

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Key concepts: Gastrin-releasing peptide, Bombesin, Gastrin, Internal medicine, Endocrinology, Peptide, Gastrointestinal hormone, G cell