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Imerslund-Gräsbeck Syndrome in two Brothers: Renal Biopsy and Ultrastructural Findings

Dandan Liang, H C Hsu, F Y Huang, Kuang‐Yu Wei

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Abstract

In two Chinese siblings with Imerslund-Gräsbeck syndrome, light microscopy of renal biopsies showed no remarkable change. Ultrastructurally, there were small possible focal defects in the glomerular basement membrane. Neither podocytes nor tubular cells showed evident change. No electron dense deposit was found. Our observations on renal ultrastructure differ from the previous five reports. The literature on renal pathology of this syndrome is reviewed.

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What this paper is about

In two Chinese siblings with Imerslund-Gräsbeck syndrome, light microscopy of renal biopsies showed no remarkable change. Ultrastructurally, there were small possible focal defects in the glomerular basement membrane. Neither podocytes nor tubular cells showed evident change. No electron dense deposit was found. Our observations on renal ultrastructure differ from the previous five reports. The literature on renal pathology of this syndrome is reviewed.

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OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In two Chinese siblings with Imerslund-Gräsbeck syndrome, light microscopy of renal biopsies showed no remarkable change. Ultrastructurally, there were small possible focal defects in the glomerular basement membrane. Neither podocytes nor tubular cells showed evident change. No electron dense deposit was found. Our observations on renal ultrastructure differ from the previous five reports. The literature on renal pathology of this syndrome is reviewed.

Key concepts: Ultrastructure, Medicine, Pathology, Renal biopsy, Glomerular basement membrane, Basement membrane, Electron microscope, Biopsy

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