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Polypoid change of the glomerular basement membrane.

Martin Sa, Kissane Jm

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Abstract

A peculiar and previously undescribed alteration in the glomerular basement membrane, which we designate as polypoid change, was found in a 4-year-old child with mongolism (trisomy 21). Light and electron microscopical studies were performed. Although the pathogenesis and significance of this lesion remain uncertain, we have compared the lesion with known processes that affect the glomerular basement membrane.

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What this paper is about

A peculiar and previously undescribed alteration in the glomerular basement membrane, which we designate as polypoid change, was found in a 4-year-old child with mongolism (trisomy 21). Light and electron microscopical studies were performed. Although the pathogenesis and significance of this lesion remain uncertain, we have compared the lesion with known processes that affect the glomerular basement membrane.

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Available abstract

A peculiar and previously undescribed alteration in the glomerular basement membrane, which we designate as polypoid change, was found in a 4-year-old child with mongolism (trisomy 21). Light and electron microscopical studies were performed. Although the pathogenesis and significance of this lesion remain uncertain, we have compared the lesion with known processes that affect the glomerular basement membrane.

Key concepts: Basement membrane, Glomerular basement membrane, Lesion, Basement, Pathology, Pathogenesis, Electron microscope, Anatomy

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