2009•Acta HaematologicaRequires access
Thrombopoietin Activity in Mice Following Immune-Induced Thrombocytopenia
Alexander Nakeff, K. J. Roozendaal
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Abstract
Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the kinetics of megakaryocyte production.