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2008•Chinese journal of integrated traditional and Western medicineRequires access

The role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia

XU An-gao

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Abstract

Objective:To explore the role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia.Methods:The serum thrombopoietin levels,prothrombin activity,bone marrow megakaryocyte count were measured in 76 chronic hepatitis B patients with thrombocytopenia.Results:The serum thrombopoietin levels were correlated with parameters including coagulation activation,bone marrow megakaryocyte count,the platelet count(r was 0.423,0.396,0.297 respectively,P0.05).The bone marrow megakaryocyte count was below(7/4.5cm2) in 22 out of 76 patients.Megakaryocyte was dysmaturity in 29 out of 76 patients.Conclusion:The results suggest that decline of thrombopoietin may contribute to thrombocytopenia in chronic hepatitis B patients.

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What this paper is about

Objective:To explore the role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia.Methods:The serum thrombopoietin levels,prothrombin activity,bone marrow megakaryocyte count were measured in 76 chronic hepatitis B patients with thrombocytopenia.Results:The serum thrombopoietin levels were correlated with parameters including coagulation activation,bone marrow megakaryocyte count,the platelet count(r was 0.423,0.396,0.297 respectively,P0.05).The bone marrow megakaryocyte count was below(7/4.5cm2) in 22 out of 76 patients.Megakaryocyte was dysmaturity in 29 out of 76 patients.Conclusion:The results suggest that decline of thrombopoietin may contribute to thrombocytopenia in chronic hepatitis B patients.

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Available abstract

Objective:To explore the role of thrombopoietin in chronic hepatitis B patients with thrombocytopenia.Methods:The serum thrombopoietin levels,prothrombin activity,bone marrow megakaryocyte count were measured in 76 chronic hepatitis B patients with thrombocytopenia.Results:The serum thrombopoietin levels were correlated with parameters including coagulation activation,bone marrow megakaryocyte count,the platelet count(r was 0.423,0.396,0.297 respectively,P0.05).The bone marrow megakaryocyte count was below(7/4.5cm2) in 22 out of 76 patients.Megakaryocyte was dysmaturity in 29 out of 76 patients.Conclusion:The results suggest that decline of thrombopoietin may contribute to thrombocytopenia in chronic hepatitis B patients.

Key concepts: Thrombopoietin, Megakaryocyte, Medicine, Platelet, Bone marrow, Prothrombin time, Chronic hepatitis, Internal medicine

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