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1994•Clinical GeneticsOpen access

Allele frequencies of Mp6D‐9 and GATT markers in 32 Turkish cystic fibrosis families

Meral Özgüç, Engin Yılmaz, H. Erdem, Teoman Coşkun, Uğur Özçelik, İnci̇ Togan, Ayhan Göçmen, S Ayter, İ Özalp

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Abstract

The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.

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What this paper is about

The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.

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Available abstract

The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.

Key concepts: Allele, Haplotype, Cystic fibrosis, Genetics, Turkish population, Biology, ΔF508, Allele frequency

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