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2004•Chemistry LettersRequires access

Separation of Warfarin Enantiomers by Capillary Gas Chromatography with Chiral Stationary Phase

Iwao Abe, Daiki Nagamatsu, Taketoshi Nakahara, Gerd Fabian

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Abstract

Abstract Warfarin was converted into O-perfluoroacyl derivatives and separated into enantiomers by capillary GC with chiral stationary phase of polydimethylsiloxane anchored with S(−)-t-leucine-S(−)-1-phenylethylamide. All the derivatives showed almost complete separation. Especially in the case of O-heptafluorobutyryl derivative, baseline separation could be observed.

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What this paper is about

Abstract Warfarin was converted into O-perfluoroacyl derivatives and separated into enantiomers by capillary GC with chiral stationary phase of polydimethylsiloxane anchored with S(−)-t-leucine-S(−)-1-phenylethylamide. All the derivatives showed almost complete separation. Especially in the case of O-heptafluorobutyryl derivative, baseline separation could be observed.

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Available abstract

Abstract Warfarin was converted into O-perfluoroacyl derivatives and separated into enantiomers by capillary GC with chiral stationary phase of polydimethylsiloxane anchored with S(−)-t-leucine-S(−)-1-phenylethylamide. All the derivatives showed almost complete separation. Especially in the case of O-heptafluorobutyryl derivative, baseline separation could be observed.

Key concepts: Chemistry, Enantiomer, Chromatography, Chiral stationary phase, Capillary gas chromatography, Chiral column chromatography, Gas chromatography, Capillary electrochromatography

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