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2006•Molecular TherapyOpen access

920. Bone Regeneration with Xenogeneic BMP-2 Producing Fibroblasts

Moon Jong Noh, Chae-Lyul Lim, Jong-Pil Hyun, Hyeon-Youl Lee, Kyoung Baek Choi, Youngsuk Yi, Kwan Hee Lee

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Abstract

Bone fractures such as pelvic fracture or sternal fracture could be a serious, life-threatening event requiring emergency medical care and lengthy rehabilitation. We have selected BMP-2 as a possible answer for the treatment of severe bone fractures. BMP-2 is known as the powerful inducers of osteogenic differentiation. Due to the short half-life of BMPs in vivo, continuous production of BMPs by gene therapy could be one of the good methods for the successful regeneration of a bone defect. We have tested ex-vivo approach for the regeneration of critical sized bone defect.

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Bone fractures such as pelvic fracture or sternal fracture could be a serious, life-threatening event requiring emergency medical care and lengthy rehabilitation. We have selected BMP-2 as a possible answer for the treatment of severe bone fractures. BMP-2 is known as the powerful inducers of osteogenic differentiation. Due to the short half-life of BMPs in vivo, continuous production of BMPs by gene therapy could be one of the good methods for the successful regeneration of a bone defect. We have tested ex-vivo approach for the regeneration of critical sized bone defect.

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Available abstract

Bone fractures such as pelvic fracture or sternal fracture could be a serious, life-threatening event requiring emergency medical care and lengthy rehabilitation. We have selected BMP-2 as a possible answer for the treatment of severe bone fractures. BMP-2 is known as the powerful inducers of osteogenic differentiation. Due to the short half-life of BMPs in vivo, continuous production of BMPs by gene therapy could be one of the good methods for the successful regeneration of a bone defect. We have tested ex-vivo approach for the regeneration of critical sized bone defect.

Key concepts: Bone morphogenetic protein 2, Regeneration (biology), Bone healing, Bone morphogenetic protein, Cortical bone, Tibia, Long bone, Diaphysis

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