2007•Chinese Journal of OsteoporosisRequires access
Effect of high calcium diet on cortical bone of aged female rats
Wong Mansa
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Abstract
Objective To investigate the healthy effect of high calcium diet on cortical bone of aged female rats. Methods According to the different calcium content in diet, rats were randomly divided into three groups, fed with low calcium diet (0.1%Ca), middle calcium diet (0.6%Ca), and high calcium diet (1.2%Ca), respectively, for 12 weeks. Parameters of cortical bone in femoral diaphysis were measured by peripheral quantitative computed tomography (pQCT).Results Bone mineral density and content of cortical bone in femoral diaphysis were significantly increased in rats fed with high dietary calcium. High calcium diet significantly elevated cortical bone area and thickness, while the periosteal and endosteal perimeter of femoral diaphysis were not altered.Conclusions High calcium diet could maintain cortical bone health by increasing cortical bone mass, area and thickness in aged female rats.