2007•Molecular Genetics and MetabolismRequires access

20 Pregnane X receptor (PXR) activation: A novel mechanism for neuroprotection in a mouse model of Niemann–Pick C disease

Daniel Ory, S. Joshua Langmade, Sarah E. Gale, Andrey Frolov, Ikuko Mohri, Kinuko Suzuki, Synthia H. Mellon, Steven U. Walkley, Douglas F. Covey, Jean Steyaert

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Key concepts: Pregnane X receptor, Farnesoid X receptor, Cholesterol 7 alpha-hydroxylase, Bile acid, G protein-coupled bile acid receptor, Bile Salt Export Pump, Internal medicine, Chemistry

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20 Pregnane X receptor (PXR) activation: A novel mechanism for neuroprotection in a mouse model of Niemann–Pick C disease — Research Paper | ScholarLens