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2007•Journal of Zhejiang University. Science ARequires access

Lovastatin production by Aspergillus terreus in solid-state fermentation

Peilian Wei, Zhinan Xu, Peilin Cen

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Abstract

Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%∼60% initial moisture content, pH 5.5, incubation temperature 28 °C.

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What this paper is about

Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%∼60% initial moisture content, pH 5.5, incubation temperature 28 °C.

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Available abstract

Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%∼60% initial moisture content, pH 5.5, incubation temperature 28 °C.

Key concepts: Aspergillus terreus, Lovastatin, Solid-state fermentation, Bran, Fermentation, Substrate (aquarium), Food science, Incubation

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