2013•Applied Mechanics and MaterialsOpen access

The Effect and Mechanism of Apoptosis Induced by Desacetylcinobufotalin (DEBF) in Human Hepatocellular Carcinoma HepG2 Cells

Chao Xu, Lin Dang, Min Wei

Abstract

The cytotoxicity of Desacetylcinobufotalin (DEBF) and apoptosis induced by DEBF was measured. Additionally the mechanism of Apoptosis induced by DEBF was studied through Western blot. The results show DEBF displayed the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml. The expression of Bax was significantly increased and the expression of Bcl-2 was markedly decreased, compared to the control. The data suggest DEBF had significant antitumor activity through induction apoptosis via mitochondria pathway.

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Key concepts: Apoptosis, Hepatocellular carcinoma, Western blot, Cytotoxicity, Chemistry, Mechanism (biology), BAX Protein, Molecular biology