1985•Journal of Pharmacy and PharmacologyRequires access

The effect of nifedipine and verapamil on the pendular movements of the rabbit isolated ileum

D.B. Beleslin, Ranka Samardžić, Branka Terzić, D Jovanović-Micić

Abstract

The inhibitory effect of calcium antagonists such as nifedipine and verapamil on the pendular movements of the rabbit isolated ileum was investigated. Nifedipine and verapamil depressed or abolished the pendular movements. The inhibitory effects of nifedipine and verapamil were concentration-dependent. Nifedipine is about 1000 times more potent than verapamil. Calcium ions failed to reverse the inhibitory effects of nifedipine and verapamil. Calcium antagonists which influence the motor activity of the digestive tract, therefore, could have therapeutic use independent of their action on the cardiovascular system.

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Key concepts: Verapamil, Nifedipine, Ileum, Calcium, Inhibitory postsynaptic potential, Pharmacology, Chemistry, Internal medicine