1997•Synthetic CommunicationsRequires access

N-tert-Butoxycarbonyl (BOC) Deprotection Using Boron Trifluoride Etherate

Emily F. Evans, Norman J. Lewis, Isabelle Kapfer, Gregor J. Macdonald, Richard J. K. Taylor

Abstract

A mild and efficient procedure is described for the removal of the tert-butoxycarbonyl (BOC) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

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Key concepts: Boron trifluoride, Chemistry, Dichloromethane, Boron, Trifluoride, Scope (computer science), Organic chemistry, Molecular sieve