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2010•Naunyn-Schmiedeberg s Archives of PharmacologyRequires access

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

Sabrina Obers, Ingo Staudacher, Eckhard Ficker, Adrienne T. Dennis, Ronald Koschny, Hande Erdal, Ramona Bloehs, Jana Kisselbach, Christoph A. Karle, Patrick A. Schweizer, Hugo A. Katus, Dierk Thomas

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Key concepts: hERG, Potassium channel blocker, Pharmacology, Potassium channel, HEK 293 cells, Chemistry, Patch clamp, Cell biology

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Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine — Research Paper | ScholarLens