1993•GlycobiologyRequires access
The vascular E-selectin binds to the leukocyte integrins CD11/CD18
Pekka Kotovuori, E Tontti, R Pigott, Maura Shepherd, Makoto Kiso, Akira Hasegawa, Risto Renkonen, Pekka Nortamo, Dario C. Altieri, Carl G. Gahmberg
Open publisher page 84 citations
Abstract
Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.