ScholarLens Back to search
2000•Expert Opinion on Therapeutic PatentsRequires access

Matrix metalloproteinase inhibitors and cancer

Janelle L. Lauer‐Fields, Gregg B. Fields

Open publisher page 9 citations

Abstract

The matrix metalloproteinase (MMP) family plays an integral role in both normal and pathological connective tissue remodeling. The accelerated local turnover of the extracellular matrix is often found in tumour cell invasion and metastasis. The development of MMP inhibitors thus offers a promising strategy to modulate metastasis. This review describes developments in MMP inhibitor research and patents related to cancer since 1998.

About this research paper

What this paper is about

The matrix metalloproteinase (MMP) family plays an integral role in both normal and pathological connective tissue remodeling. The accelerated local turnover of the extracellular matrix is often found in tumour cell invasion and metastasis. The development of MMP inhibitors thus offers a promising strategy to modulate metastasis. This review describes developments in MMP inhibitor research and patents related to cancer since 1998.

Why it matters

OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The matrix metalloproteinase (MMP) family plays an integral role in both normal and pathological connective tissue remodeling. The accelerated local turnover of the extracellular matrix is often found in tumour cell invasion and metastasis. The development of MMP inhibitors thus offers a promising strategy to modulate metastasis. This review describes developments in MMP inhibitor research and patents related to cancer since 1998.

Key concepts: Matrix metalloproteinase, Extracellular matrix, Metastasis, Cancer, Cancer research, Matrix metalloproteinase inhibitor, Cancer metastasis, Tissue inhibitor of metalloproteinase

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Matrix metalloproteinase inhibitors and cancer — Research Paper | ScholarLens