1999•PubMedRequires access

[Cancer metastasis and extracellular matrix].

Naoki Itano, Yasuhiro Yamada, M Yoshida, K Kimata

Abstract

We investigated the roles of the extracellular matrix, especially of hyaluronan, in cancer metastasis. A positive relationship was shown between hyaluronan synthetic activity and the metastatic ability of cancer cells by manipulating regulation of gene expression of hyaluronan synthases. These techniques may provide future therapeutic methods for cancer metastasis.

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Key concepts: Extracellular matrix, Metastasis, Cancer metastasis, Cancer, Cancer cell, Cancer research, Extracellular, Biology