2008•Nucleic Acids Symposium SeriesRequires access

Synthesis and properties of covalently linked antiparallel and parallel DNA duplexes

Toshikazu Ono, Y. Saotome, I. Okamoto, Akira Mei Ono

Abstract

We synthesized covalently linked antiparallel stranded (aps) and parallel stranded (ps) DNA duplexes. These modified duplexes contained an ethylene-linked T-T base pair at the duplex end. Thermal denaturation analysis of these modified duplexes indicated that the aps and ps DNA duplexes have similar thermal stabilities.

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Key concepts: Antiparallel (mathematics), Covalent bond, DNA, Chemistry, Crystallography, Stereochemistry, Biochemistry, Physics