2006•Journal of the American Chemical SocietyRequires access

An Antiparallel α-Helical Coiled-Coil Model System for Rapid Assessment of Side-Chain Recognition at the Hydrophobic Interface

Erik B. Hadley, Samuel H. Gellman

Abstract

Both parallel and antiparallel alpha-helical coiled-coil dimers are common among proteins; however, biophysical scrutiny has focused almost entirely on parallel dimers. We describe the development of a model system that enables efficient and systematic analysis of hydrophobic packing between antiparallel alpha-helices. Our findings reveal significant differences in packing preferences between parallel and antiparallel coiled-coils.

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Key concepts: Antiparallel (mathematics), Chemistry, Coiled coil, Crystallography, Biochemistry, Physics, Quantum mechanics, Magnetic field