2009•International Archives of Allergy and Applied ImmunologyRequires access
Interaction among IgE-Mediated Hypersensitivity Reaction, PCA Reaction and Delayed Hypersensitivity Reaction (at Local Skin Sites of Monkeys)
Takami Yoshida, Harukí Mikawa, Keisuke Shinomiya, Takao Hirao, Rokuro Okuda
Open publisher page 2 citations
Abstract
The effect of the IgE-mediated reaction on the passive cutaneous anaphylaxis (PCA) reaction was studied at local skin sites of monkeys, and we found that the IgE-mediated reaction appeared to enhance the PCA reaction. Interactions among IgE-mediated reaction, PCA reaction and delayed hypersensitivity reaction were also determined. Contact dermatitis induced with DNCB was utilized as the delayed hypersensitivity reaction. The IgE-mediated reactior or PCA reaction, as well as simple serum irritation, enhanced the delayed hypersensitivity reaction. It is thus assumed that the IgE-mediated reaction enhances the PCA reaction and that this in turn accelerates the delayed hypersensitivity reaction.