2006•Critical Reviews in Analytical ChemistryRequires access

Application of Factorial and Response Surface Methodology in Modern Experimental Design and Optimization

Grady Hanrahan, Kenneth Lu

Abstract

This article critically examines the use of factorial and response surface methodology in modern experimental design and optimization. A survey of important screening and optimization techniques in the literature since 2000 are presented. Current applications in biological, environmental and pharmaceutical analysis, food technology and industrial-related processes are examined.

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Key concepts: Response surface methodology, Factorial experiment, Biochemical engineering, Design of experiments, Fractional factorial design, Computer science, Factorial, Management science