P53 Expression in Adenomyosis in Endometrial Carcinoma Patients

In studies on endometrial adenocarcinoma, tumor supres-Histopathologic changes ranging from simple cystic hyperplasia sor genes, in particular P53, is thought to play a role in the to carcinoma in situ may be observed in adenomyotic foci in patransformation and more importantly in the progression of tients with endometrial carcinoma.These changes can be an area the neoplasm [4][5][6].However, to the best of our knowledge, of concern and physicians should be aware of their clinicopatho-P53 has not been studied in adenomyosis and its association logic significance.We studied a total of 94 patients, including with endometrial carcinoma.Does P53 play a role in the endometrial carcinoma with (28 patients) and without adenoproliferative changes in adenomyosis?myosis (56 patients), and control group of adenomyosis cases (10 In this study, we surveyed the incidence of histopathologipatients) without endometrial carcinoma.The histopathological cal changes seen in adenomyosis in 84 consecutive endomechanges in adenomyosis in patients with endometrial carcinoma trial carcinomas and 10 control adenomyosis-only cases.In varied from endometrial glands resembling the basal endometrium addition to gathering conventional histopathological data, (13 of 28) through simple hyperplasia (8 of 28) to complex atypical hyperplasia, resembling carcinoma in situ (7 of 28).Formalin-we searched for P53 alterations in both the endometrial carcifixed paraffin-embedded tissues from 55 patients (45 endometrial noma and adenomyosis.carcinomas and 10 control adenomyosis) were stained with monoclonal antibodies against P53.P53 positivity was not detected in MATERIALS AND METHODS adenomyosis cases without endometrial carcinoma but was presentThis study includes a total of 94 patients, 84 of them with in 7 of the endometrial carcinoma-related cases.P53 positivity was endometrial carcinoma, who had undergone hysterectomy at found in 14 of 45 endometrial carcinomas studied.In all of the adenomyosis-positive cases, the endometrium was also positive.In Lenox Hill Hospital, New York City, from 1989 to 1992 conclusion, adenomyosis with a range of hyperplastic to atypical and 10 patients with adenomyosis without carcinoma, who changes is not uncommon in adenocarcinoma patients.Our findhad also undergone hysterectomy in the same period, as ings regarding P53 positivity in adenomyosis are consistent with a control group.We reviewed all available hematoxylenthe hypothesis that hyperplastic and atypical changes in adenophiloxine-saffrone (HPS)-stained slides for tumor grade acmyosis might be due to a carcinogenic field effect in the vicinity cording to current FIGO criteria, the depth of myometrial of endometrial carcinoma rather than by direct invasion.᭧ 1996 invasion, the presence of adenomyosis, and, if present, the Academic Press, Inc.type of histopathological changes in the adenomyosis.Adenomyosis was defined as the presence of endometrial glands and stroma in the myometrium deeper than one-half of a