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Graft versus Leukemia: Quantification of Adoptive Immunotherapy in Murine Leukemia

Mortimer M. Bortin, Alfred A. Rimm, Edward C. Saltzstein

Abstract

Quantification of the antileukemic reactivity of transplanted immunocompetent cells from various allogeneic donors was achieved against a long-passage lymphocytic leukemia of AKR mice. Adoptive immunotherapy was the exclusive antileukemic treatment. Cells from DBA/2 donors exhibited maximal antileukemic effect, inactivating up to an estimated 10(7) leukemia cells. The cellular events were interpreted by using a theoretical cytokinetic construct.

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Key concepts: Adoptive immunotherapy, Leukemia, Immunotherapy, Adoptive cell transfer, Medicine, Cancer research, Immunology, Immune system