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High‐Yield Formation of Arbutin from Hydroquinone by Cell‐Suspension Cultures of Rauwolfia serpentina

Ralf Lutterbach, Joachim Stöckigt

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Abstract

Abstract High‐density cell‐suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant‐cell‐culture systems reported to date.

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What this paper is about

Abstract High‐density cell‐suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant‐cell‐culture systems reported to date.

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Available abstract

Abstract High‐density cell‐suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant‐cell‐culture systems reported to date.

Key concepts: Arbutin, Hydroquinone, Chemistry, Yield (engineering), Glycoside, Suspension culture, Botany, Cell culture

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High‐Yield Formation of Arbutin from Hydroquinone by Cell‐Suspension Cultures of Rauwolfia serpentina — Research Paper | ScholarLens