2013•Journal of Pharmaceutical SciencesRequires access

A Mechanistic Physiologically Based Pharmacokinetic-Enzyme Turnover Model Involving both Intestine and Liver to Predict CYP3A Induction-Mediated Drug–Drug Interactions

Haifang Guo, Can Liu, Jia Li, Mian Zhang, Mengyue Hu, Ping Xu, Li Liu, Xiaodong Liu

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Key concepts: Physiologically based pharmacokinetic modelling, CYP3A, Cmax, Pharmacokinetics, Pharmacology, Chemistry, Drug metabolism, Cytochrome P450

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A Mechanistic Physiologically Based Pharmacokinetic-Enzyme Turnover Model Involving both Intestine and Liver to Predict CYP3A Induction-Mediated Drug–Drug Interactions — Research Paper | ScholarLens